![]() Repeatability was assessed by performing replicate measurements. EELV was computed at each PEEP step by both the MBNW technique (EELV MBNW) and CT (EELV CT). Seven pigs were studied in 6 experimental conditions: at baseline, after experimental ARDS and during a decremental PEEP trial at PEEP 16, 12, 6 and 2 cmH 2O. The secondary aims of the study were: (1) to evaluate trending ability of the novel system to assess EELV (2) to evaluate the reliability of estimated alveolar recruitment induced by positive end-expiratory pressure (PEEP) changes computed from EELV MBNW, using CT as the gold standard. The primary aim of the study was to evaluate the reliability of a novel MBNW bedside system using fast mainstream sensors to assess EELV in an experimental acute respiratory distress syndrome (ARDS) model, using computed tomography (CT) as the gold standard. The multiple-breaths nitrogen washin–washout (MBNW) technique is currently available to measure end-expiratory lung volume (EELV MBNW), but the precision of the technique may be poor, with percentage errors ranging from 28 to 57%. Personalizing mechanical ventilation requires the development of reliable bedside monitoring techniques.
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